Planta Med 2014; 80(06): 502-508
DOI: 10.1055/s-0034-1368299
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Xanthone Glycosides from Swertia bimaculata with α-Glucosidase Inhibitory Activity

Yao-Dong Yue
1   Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, Peopleʼs Republic of China
,
Yu-Tang Zhang
1   Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, Peopleʼs Republic of China
,
Zhao-Xia Liu
1   Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, Peopleʼs Republic of China
,
Qiu-Xia Min
1   Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, Peopleʼs Republic of China
,
Luo-Sheng Wan
1   Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, Peopleʼs Republic of China
,
Yong-Long Wang
1   Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, Peopleʼs Republic of China
,
Zuo-Qi Xiao
1   Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, Peopleʼs Republic of China
,
Jia-Chun Chen
1   Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, Peopleʼs Republic of China
› Author Affiliations
Further Information

Publication History

received 27 October 2013
revised 01 January 2014

accepted 25 February 2014

Publication Date:
31 March 2014 (online)

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Abstract

Seven new xanthone glycosides (17) were isolated from the n-butanol extract of Swertia bimaculata, together with six known compounds (813). Their structures were elucidated on the basis of extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. All the compounds were evaluated for their α-glucosidase inhibitory activities in vitro, and compounds 3, 4, and 7 exhibited significant activities to inhibit α-glucosidase. Meanwhile the effects of different substitutions on the α-glucosidase inhibitory activity of xanthone glycosides from S. bimaculata are also discussed.

Supporting Information